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– Five posters will showcase progress with multiple preclinical and clinical programs, including the clinical results of ATG-008 (mTORC1/2 inhibitor) and preclinical data of ATG-031 (anti-CD24 monoclonal antibody), ATG-037 (small molecule CD73 inhibitor), ATG-017 (ERK1/2 inhibitor), and ATG-034 (LILRB4 antagonist antibody)
SHANGHAI and HONG KONG, March 20, 2023 /PRNewswire/ — Antengene Corporation Limited ("Antengene" SEHK: 6996.HK), a leading innovative, global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, today announced the publication of abstracts for five posters that will be presented during the upcoming 2023 American Association for Cancer Research Annual Meeting (AACR 2023), taking place from April 14th to 19th at the Orange County Convention Center in Orlando, Florida, the United States.
"We are honored to have the opportunity to present the latest results from our in-house discovery and clinical programs at AACR 2023. This year, we have five abstracts selected for presentations at the AACR Annual Meeting. These results underscore our focus on the tumor microenvironment and the unique role that immunology plays in cancer, including our expertise in discovering and developing small molecule and unique antibody drugs," said Dr. Bo Shan, Antengene’s Chief Scientific Officer. "Building these progress, we will continue to accelerate our preclinical and clinical programs in efforts to bring more innovative treatment options to patients as soon as possible."
Details of the posters and corresponding abstracts are shown below:
ATG-008 (mTORC1/2 inhibitor)
Title: Result of an open-label phase 2 trial of dual TORC1/TORC2 inhibitor onatasertib(ATG-008) in HBV+ advanced hepatocelllular carcinoma(HCC) subjects who have received at least one prior line of systemic therapy(TORCH)
Abstract: CT150
Session: Phase II Clinical Trials 1
Date: April 17, 2023
Time: 1:30 PM – 5:00 PM (Eastern Time)
1:30 AM – 5:00 AM, April 18, 2023 (Beijing Time)
Location: Poster Section 47
ATG-031 (anti-CD24 monoclonal antibody)
Title: ATG-031, a first-in-class humanized anti-CD24 antibody, demonstrates potent in vivo efficacy and repolarizes tumor-associated macrophages in the TME
Abstract: 6641
Session: Immune Checkpoints
Date: April 19, 2023
Time: 9:00 AM – 12:30 PM (Eastern Time)
9:00 PM April 19 – 12:30 AM April 20, 2023 (Beijing Time)
Location: Poster Section 38
ATG-037 (small molecule CD73 inhibitor)
Title: Targeting CD73-Adenosine Axis for the treatment of multiple myeloma
Abstract: 496
Session: Novel Antitumor Agents 1
Date: April 16, 2023
Time: 1:30 PM – 5:00 PM (Eastern Time)
1:30 AM – 5:00 AM, April 17, 2023 (Beijing Time)
Location: Poster Section 17
ATG-017 (ERK1/2 inhibitor)
Title: Synergistic effects of the combination of ERK1/2 with EGFR, KRASG12C, CDK4/6, and PD-L1 inhibition for cancer treatment
Abstract: 5499
Session: Combination Therapies for Cancer
Date: April 18, 2023
Time: 1:30 PM – 5:00 PM (Eastern Time)
1:30 AM – 5:00 AM, April 19, 2023 (Beijing Time)
Location: Poster Section 38
ATG-034 (LILRB4 antagonist antibody)
Title: ATG-034, an LILRB4 antagonist antibody, reinvigorates dendritic cells and prevents tumor progression
Abstract: 6384
Session: Immune Checkpoints
Date: April 19, 2023
Time: 9:00 AM – 12:30 PM (Eastern Time)
9:00 PM April 19 – 12:30 AM April 20, 2023 (Beijing Time)
Location: Poster Section 23
About Antengene
Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) is a leading commercial-stage R&D-driven global biopharmaceutical company focused on the discovery, development, manufacturing and commercialization of innovative first-in-class/best-in-class therapeutics for the treatment of hematologic malignancies and solid tumors, in realizing its vision of "Treating Patients Beyond Borders".
Since 2017, Antengene has built a broad and expanding pipeline of 13 clinical and preclinical assets, of which 10 are global rights assets, and 3 came with rights for Asia Pacific markets including the Greater China region. To date, Antengene has obtained 28 investigational new drug (IND) approvals in the U.S. and Asia, and submitted 9 new drug applications (NDAs) in multiple Asia Pacific markets, with the NDA for XPOVIO® (selinexor) already approved in Mainland of China, Taiwan,China, South Korea, Singapore and Australia.
Forward-looking statements
The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement, see the section titled "Risk Factors" in our periodic reports filed with the Hong Kong Stock Exchange and the other risks and uncertainties described in the Company’s Annual Report for year-end December 31, 2021, and subsequent filings with the Hong Kong Stock Exchange.
For more information, please contact:
Investor Contacts:
Donald Lung
E-mail: Donald.Lung@antengene.com
Mobile: +86 18420672158
PR Contacts:
Peter Qian
E-mail: Peter.Qian@antengene.com
Mobile: +86 13062747000